While primarily known as a photographer, at various times Fred supplemented his income through working as a newsagent and stationer, a dealer in antiques and photographic equipment and, of course, as a postcard seller. It is not known for certain why his photographic work declined. It may have been that other areas of his family business proved more profitable. When the postcard postage rate was doubled to 1d in 1918 the interest for this type of communication waned – and with it the demand for Fred's extensive postcard production.
After the horrors of the First World War, the 1920s heralded a new age of optimism, where the rigid order of the Victorian and Edwardian eras quickly lost its appeal. Fred's vision of a bygone Bristol must have suddenly appeared archaic and obsolete.
The business was bought by H. Salanson & Co Ltd around 1937. They seem to have purchased at least some of his stock, as a number of postcards exist with the new owners’ details rubber-stamped on their reverse. These were presumably used as rather novel compliment slips for Salanson’s customers. Bafflingly some others were stamped "CANCELLED This is not a Postcard". While this has never been satisfactorily explained, it proved to be the final indignity for Fred's work.
The World War II bombing raids on Bristol were to wipe out many of the locations of his pictures. Today nothing remains in the city centre to show where Fred lived and worked.
After retiring, Fred moved to Failand in Somerset. He lived there until 1953 when he returned briefly to Bristol. He died in Bishopston on 11 February of that year. His body was transported to Failand for burial in the grounds of St Bartholomew’s Church, where his grave overlooks a beautiful valley.
Since the 1970s, historians have become increasingly interested in Bristol's 20th century history; simultaneously postcard collecting has grown in popularity. Reece Winstone published many volumes of the 'Bristol As It Was' series. These featured many Fred Little images, although few were credited as his photographs. Numerous photographic histories of Bristol have since been issued – and most include images that came from the camera of Frederick George Little.